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PMC 5709737

Simultaneous Fenton-like ion delivery and glutathione depletion by MnO(2) -based nanoagent to enhance chemodynamic therapy

Copper also mediates the activation of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) in cancer cells, enabling immune evasion

Furthermore, the secretion of the CCL2 chemokine by astrocytes is essential for the stemness of MB cells and the generation of metastases throughout the CNS (304, 305)